Ongoing discoveries in pharmacogenetics field are expanding drug metabolism in directions that lead to the future prospect of truly individualized drug regimens. The principles presented in this elective course will help to keep abreast of these new developments and applications in pharmacotherapy. This course will focus on fundamentals of drug metabolism, metabolic pathways, different CYP isoforms involved and their role in drug metabolism. General drug metabolic pathways (e.g. oxidation, reduction, conjugation), the induction and inhibition of CYP450 enzymes and their role in drug toxicity, drug-drug interactions, drug-food interactions, idiosyncratic reactions, and chemical carcinogenesis will also be discussed. Credits 2. 2 Lecture Hours.
Ongoing discoveries in pharmacogenetics field are expanding drug metabolism in directions that lead to the future prospect of truly individualized drug regimens. The principles presented in this elective course will help to keep abreast of these new developments and applications in pharmacotherapy. This course will focus on fundamentals of drug metabolism, metabolic pathways, different CYP isoforms involved and their role in drug metabolism. General drug metabolic pathways (e.g. oxidation, reduction, conjugation), the induction and inhibition of CYP450 enzymes and their role in drug toxicity, drug-drug interactions, drug-food interactions, idiosyncratic reactions, and chemical carcinogenesis will also be discussed. Credits 2. 2 Lecture Hours.
