The biotransformation of drugs, pesticides, carcinogens and other foreign chemicals in animals and humans. The biochemical mechanisms responsible, particularly the cytochrome P-450 mono-oxygenases, will be emphasized. The formation of toxic reactive metabolites and their effects will be discussed. Enrolment restricted. This course is not eligible for Credit/D/Fail grading.
The biotransformation of drugs, pesticides, carcinogens and other foreign chemicals in animals and humans. The biochemical mechanisms responsible, particularly the cytochrome P-450 mono-oxygenases, will be emphasized. The formation of toxic reactive metabolites and their effects will be discussed. Enrolment restricted. This course is not eligible for Credit/D/Fail grading.
