(3 units). Lecture and seminar course with emphasis on translational aspects of biomedical research towards a better understanding of the molecular and pathophysiological mechanisms of human kidney disease as related to vascular dysfunction. Topics to include: basic structure and physiology of the kidney; the endothelium in hypertension and chronic kidney disease; aldosterone in hypertension and kidney disease; acute kidney injury – impact on the renal vasculature; the sympathetic nervous system in patients with hypertension and chronic kidney disease; preclinical models of renal diseases - towards translation to humans; the glomerular filtration barrier - hemodynamic & non-hemodynamic mechanisms of injury. Course Component: Lecture Previously CMM 8355.
(3 units). Lecture and seminar course with emphasis on translational aspects of biomedical research towards a better understanding of the molecular and pathophysiological mechanisms of human kidney disease as related to vascular dysfunction. Topics to include: basic structure and physiology of the kidney; the endothelium in hypertension and chronic kidney disease; aldosterone in hypertension and kidney disease; acute kidney injury – impact on the renal vasculature; the sympathetic nervous system in patients with hypertension and chronic kidney disease; preclinical models of renal diseases - towards translation to humans; the glomerular filtration barrier - hemodynamic & non-hemodynamic mechanisms of injury. Course Component: Lecture Previously CMM 8355.
