(3 units). This course will introduce the Adverse Outcome Pathway (AOP) framework and how it can be used to support the integration of modern test methods (e.g. in silico, in vitro, high throughput, etc..) into the chemical risk assessment process. Students will first learn about current practices and recent advances in both human health and ecological chemical risk assessment. Then students will receive an advanced introduction to the AOP framework, including the theory of AOPs, how they can be used in regulatory toxicology for facilitating the use of mechanistic data, test paradigm development, and risk assessment, and training on best practices for contributing to the AOP knowledge base. This will include in-class case studies on AOP development and a final assignment where student will be responsible for developing a novel AOP for a specific toxicity. Course Component: Lecture
(3 units). This course will introduce the Adverse Outcome Pathway (AOP) framework and how it can be used to support the integration of modern test methods (e.g. in silico, in vitro, high throughput, etc..) into the chemical risk assessment process. Students will first learn about current practices and recent advances in both human health and ecological chemical risk assessment. Then students will receive an advanced introduction to the AOP framework, including the theory of AOPs, how they can be used in regulatory toxicology for facilitating the use of mechanistic data, test paradigm development, and risk assessment, and training on best practices for contributing to the AOP knowledge base. This will include in-class case studies on AOP development and a final assignment where student will be responsible for developing a novel AOP for a specific toxicity. Course Component: Lecture
